The infection, doctors believed, likely started as a urinary tract infection. In classic Applegate fashion, she met the moment with humor — even when medical staff asked an eyebrow-raising question.
Christina Applegate at the 26th Annual Screen Actors Guild Award in Los Angeles, California on January 17, 2020. | Source: Getty Images
She recalled how they questioned if she was “wiping correctly.” In response, Applegate laughed off the suggestion and noted that she is meticulous about personal hygiene, joking that she keeps herself “a clean girl down yonder.” But behind the laughter lurked concern, as doctors were not ruling out something far more serious.
Christina Applegate pictured at an event on January 12, 2020. | Source: Getty Images
“And now they’re thinking it could be something else, and I don’t want to say what they think, um, because I don’t want it to sound scary, but, um, I’m just going to be here,” she said ominously.
The stay was more than just physically draining. Emotionally, Applegate broke down, relying on nurses for comfort and distracting herself with hospital ice, mindless TV, and what she called “bedrotting” — hours spent simply trying to survive.
Christina Applegate speaks onstage during the Light Up The Blues 7 Concert celebrating Autism Speaks’ 20th Anniversary in Los Angeles, California on April 26, 2025. | Source: Getty Images
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